New Drugs

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New Drug Discoveries

Over the past two years, medical news have been busy with new drug discoveries..... Neurological conditions that have been known for long time as non-curable, now the cure is available....

DrugNeurological DisorderMechanism of ActionCompanyYear of approval
Spinraza (nusinersen)Spinal Muscle AtrophyAntisense oligonucleotide (ASO) designed to treat SMA caused by mutations in chromosome 5q that lead to SMN protein deficiencyBiogen2016
Radicava (edaravone)Amyotrophic Lateral SclerosisFree radical scavengerMitsubishi Tanabe Pharma 2017
Emflaza (deflazacort) Duchenne Muscular DystrophyCorticosteroid Marathon Pharmaceuticals2017
Austedo (deutetrabenazine)Huntington ChoreaVesicular monoamine transporter 2 (VMAT2) inhibitorTeva2017
Brineura (cerliponase alfa)NCL type II (infantile)Lysosomal tripeptidyl peptidaseBioMarin2017
Gocovri (amantadine)Parkinson's DyskinesiaLong acting amantadine Neurocrine Biosciences 2017
Ingrezza (valbenazine)Tardive DyskinesiaVesicular monoamine transporter 2 (VMAT2) inhibitoNeurocrine Biosciences 2017
Xadago (safinamide)Parkinson's diseaseMAO-B inhibitorNewron2017
Briviact (brivaracetam)Partial Seizures Synaptic vesicle protein 2A (SV2A)UCB2016
Carnexiv (carbamazepine)
SeizuresNa Channel Blocker (IV Carbamazepine) Lundbeck2016
Exondys 51 (eteplirsen)Duchenne Muscular Dystrophy with mutated DMD gene amenable to exon 51 skipping Oligonucleotide that binds to exon 51 of dystrophin pre-mRNA resulting in exclusion of this exon during mRNA processingSarepta 2016
Nuplazid (pimavanserin)Parkinson's Hallucinations5-HT2A inverse agonist and antagonist Acadia2016
Namzaric (memantine ER + donepezil)Moderate/Severe DementiaMemantine + DonepezilForest 2014
Northera (droxidopa)Neurogenic orthostatic hypotensionNorepinephrine Precursor Chelsea2014
Horizant (gabapentin enacarbil)RLS
Post-herpetic Neuralgia
Gabapentin ERGlaxoSmithKline2012
Neupro (Rotigotine patch)RLSnon-ergot dopamine agonistUCB2012
Nuedexta (dextromethorphan hydrobromide 20mg and quinidine sulfate 10mg)Pseudobulbar affect Dextromethorphan is a NMDA receptor antagonist and sigma-1 agonist (quinidine increases its bioavailability)Avanir2010


New Drugs

Drug NameIndicationsContraindicationsMechanism of Action Side EffectsDosage
Dichlorphenamide (Keveyis)Periodic paralysis (primary hyperkalemic and hypokalemic)- Not used with high dose aspirin (caution with low dose)
- Severe lung disease
- Severe liver disease
Carbonic anhydrase inhibitor- Sulfa drug, causes Steven Johnson syndrome
- Hypokalemia
- Metabolic acidosis
- Increased risk of falls
50mg BID
Pimavanserin (Nuplazid)Parkinson's disease psychosis (Doesn't cause motor side effects)None5HT2A, 5HT2C inverse agonist. - Prolongs QT interval
- Risk of death in patients with dementia (1.6 times more than placebo)
34mg Daily